Article
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.
Nature genetics - 1 Mar 2010
Petersen Gloria M, Amundadottir Laufey, Fuchs Charles S, Kraft Peter, Stolzenberg-Solomon Rachael Z, Jacobs Kevin B, Arslan Alan A, Bueno-de-Mesquita H Bas, Gallinger Steven, Gross Myron, Helzlsouer Kathy, Holly Elizabeth A, Jacobs Eric J, Klein Alison P, LaCroix Andrea, Li Donghui, Mandelson Margaret T, Olson Sara H, Risch Harvey A, Zheng Wei, Albanes Demetrius, Bamlet William R, Berg Christine D, Boutron-Ruault Marie-Christine, Buring Julie E, Bracci Paige M, Canzian Federico, Clipp Sandra, Cotterchio Michelle, de Andrade Mariza, Duell Eric J, Gaziano J Michael, Giovannucci Edward L, Goggins Michael, Hallmans Göran, Hankinson Susan E, Hassan Manal, Howard Barbara, Hunter David J, Hutchinson Amy, Jenab Mazda, Kaaks Rudolf, Kooperberg Charles, Krogh Vittorio, Kurtz Robert C, Lynch Shannon M, McWilliams Robert R, Mendelsohn Julie B, Michaud Dominique S, Parikh Hemang, Patel Alpa V, Peeters Petra H M, Rajkovic Aleksandar, Riboli Elio, Rodriguez Laudina, Seminara Daniela, Shu Xiao-Ou, Thomas Gilles, Tjønneland Anne, Tobias Geoffrey S, Trichopoulos Dimitrios, Van Den Eeden Stephen K, Virtamo Jarmo, Wactawski-Wende Jean, Wang Zhaoming, Wolpin Brian M, Yu Herbert, Yu Kai, Zeleniuch-Jacquotte Anne, Fraumeni Joseph F, Hoover Robert N, Hartge Patricia, Chanock Stephen J
Abstract excerpt
We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on...
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