Article

Mutations in tau protein promote aggregation by favoring extended conformations

2023-05-14

Abstract excerpt

Amyloid aggregation of the intrinsically disordered protein (IDP) tau is involved in several diseases, called tauopathies. Mutations in the gene encoding tau are responsible for a class of inherited tauopathies called frontotemporal dementia and parkinsonism linked to chromosome 17Q (FTDP-17). These mutations are thought to trigger FTDP-17 by favoring the formation of tau amyloid fibrils. This work aims at deciphe...

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Literature Corpus work: 033c853c-af08-5fad-91b3-29d357c448f1
DOI: 10.1101/2023.05.12.540512

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