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Article

Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers.

Arthritis research & therapy - 15 Apr 2011

Saevarsdottir Saedis, Ding Bo, Steinsson Kristjan, Grondal Gerdur, Valdimarsson Helgi, Alfredsson Lars, Klareskog Lars, Padyukov Leonid

Abstract excerpt

INTRODUCTION: Previous studies have provided inconsistent results on whether variants in the MBL2 gene, coding for the complement-activating mannan-binding lectin (MBL) protein, associate with rheumatoid arthritis (RA). We re-evaluated this in context of the main environmental and genetic risk factors (smoking, HLA-DRB1 'shared epitope' (SE), PTPN22*620W), which predispose to rheumatoid factor (RF) and/or...

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Source

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Identifiers

PMID: 21496252
DOI: 10.1186/ar3321
PMCID: PMC3132060

Genes

PTPN22
MBL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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