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Article

A model of a MAPK•substrate complex in an active conformation: a computational and experimental approach.

PloS one - 11 Apr 2011

Lee Sunbae, Warthaka Mangalika, Yan Chunli, Kaoud Tamer S, Piserchio Andrea, Ghose Ranajeet, Ren Pengyu, Dalby Kevin N

Abstract excerpt

The mechanisms by which MAP kinases recognize and phosphorylate substrates are not completely understood. Efforts to understand the mechanisms have been compromised by the lack of MAPK-substrate structures. While MAPK-substrate docking is well established as a viable mechanism for bringing MAPKs and substrates into close proximity the molecular details of how such docking promotes phosphorylation is an unresolved...

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Identifiers

PMID: 21494553
DOI: 10.1371/journal.pone.0018594
PMCID: PMC3073974

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