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Article

Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry.

Molecular cell - 9 Apr 2004

Lee Thomas, Hoofnagle Andrew N, Kabuyama Yukihito, Stroud James, Min Xiaoshan, Goldsmith Elizabeth J, Chen Lin, Resing Katheryn A, Ahn Natalie G

Abstract excerpt

Protein interactions between MAP kinases and substrates, activators, and scaffolding proteins are regulated by docking site motifs, one containing basic residues proximal to Leu-X-Leu (DEJL) and a second containing Phe-X-Phe (DEF). Hydrogen exchange mass spectrometry was used to identify regions in MAP kinases protected from solvent by docking motif interactions. Protection by DEJL peptide binding was observed in...

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PMID: 15068802
DOI: 10.1016/s1097-2765(04)00161-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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