Article
Accurate reconstruction of the temporal order of mutations in neoplastic progression.
Cancer prevention research (Philadelphia, Pa.) - 1 Jul 2011
Sprouffske Kathleen, Pepper John W, Maley Carlo C
Abstract excerpt
The canonical route from normal tissue to cancer occurs through sequential acquisition of somatic mutations. Many studies have constructed a linear genetic model for tumorigenesis using the genetic alterations associated with samples at different stages of neoplastic progression from cross-sectional data. The common interpretation of these models is that they reflect the temporal order within any given tumor....
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