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Article

Discovering functional modules by identifying recurrent and mutually exclusive mutational patterns in tumors.

BMC medical genomics - 14 Apr 2011

Miller Christopher A, Settle Stephen H, Sulman Erik P, Aldape Kenneth D, Milosavljevic Aleksandar

Abstract excerpt

BACKGROUND: Assays of multiple tumor samples frequently reveal recurrent genomic aberrations, including point mutations and copy-number alterations, that affect individual genes. Analyses that extend beyond single genes are often restricted to examining pathways, interactions and functional modules that are already known. METHODS: We present a method that identifies functional modules without any information...

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Identifiers

PMID: 21489305
DOI: 10.1186/1755-8794-4-34
PMCID: PMC3102606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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