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Article

Functional impact bias reveals cancer drivers.

Nucleic acids research - 1 Nov 2012

Gonzalez-Perez Abel, Lopez-Bigas Nuria

Abstract excerpt

Identifying cancer driver genes and pathways among all somatic mutations detected in a cohort of tumors is a key challenge in cancer genomics. Traditionally, this is done by prioritizing genes according to the recurrence of alterations that they bear. However, this approach has some known limitations, such as the difficulty to correctly estimate the background mutation rate, and the fact that it cannot identify...

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PMID: 22904074
DOI: 10.1093/nar/gks743
PMCID: PMC3505979

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