Article
Identification of rare cancer driver mutations by network reconstruction.
Genome research - 1 Sept 2009
Torkamani Ali, Schork Nicholas J
Abstract excerpt
Recent large-scale tumor resequencing studies have identified a number of mutations that might be involved in tumorigenesis. Analysis of the frequency of specific mutations across different tumors has been able to identify some, but not all of the mutated genes that contribute to tumor initiation and progression. One reason for this is that other functionally important genes are likely to be mutated more rarely...
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