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Article

Classifying cancer genome aberrations by their mutually exclusive effects on transcription.

BMC medical genomics - 21 Dec 2017

Dayton Jonathan B, Piccolo Stephen R

Abstract excerpt

BACKGROUND: Malignant tumors are typically caused by a conglomeration of genomic aberrations-including point mutations, small insertions, small deletions, and large copy-number variations. In some cases, specific chemotherapies and targeted drug treatments are effective against tumors that harbor certain genomic aberrations. However, predictive aberrations (biomarkers) have not been identified for many tumor...

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Identifiers

PMID: 29322935
DOI: 10.1186/s12920-017-0303-0
PMCID: PMC5763295

Genes

EGFR
MET
BRAF
PTEN
VHL

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