Article
Cooperative genomic alteration network reveals molecular classification across 12 major cancer types.
Nucleic acids research - 25 Jan 2017
Zhang Hongyi, Deng Yulan, Zhang Yong, Ping Yanyan, Zhao Hongying, Pang Lin, Zhang Xinxin, Wang Li, Xu Chaohan, Xiao Yun, Li Xia
Abstract excerpt
The accumulation of somatic genomic alterations that enables cells to gradually acquire growth advantage contributes to tumor development. This has the important implication of the widespread existence of cooperative genomic alterations in the accumulation process. Here, we proposed a computational method HCOC that simultaneously consider genetic context and downstream functional effects on cancer hallmarks to...
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