Article
Characterization of domain deletion and/or duplication mutants of a recombinant chimera of tissue-type plasminogen activator and urokinase-type plasminogen activator (rt-PA/u-PA).
Thrombosis and haemostasis - 13 Aug 1990
Nelles L, Lijnen H R, Van Nuffelen A, Demarsin E, Collen D
Abstract excerpt
Chimeric molecules comprising the A-chain of tissue-type plasminogen activator (t-PA) and the catalytic domain of urokinase-type plasminogen activator (u-PA) have intact enzymatic characteristics of u-PA, but only partial fibrin-binding properties of t-PA (Nelles et al., J Biol Chem 1987; 262: 10...
Topics
- Affinity Labels
- Amino Acid Sequence
- Amino Acids
- Culture Media
- Fibrin
- Fibrinogen
- Fibrinolysin
- Humans
- Molecular Sequence Data
- Mutation
- Plasminogen Activators
- Protein Binding
- Recombinant Fusion Proteins
- Sepharose
- Tissue Plasminogen Activator
- Urokinase-Type Plasminogen Activator