Article
Structural determinants of the noncatalytic chain of tissue-type plasminogen activator that modulate its association rate with plasminogen activator inhibitor-1.
The Journal of biological chemistry - 25 Jun 1990
de Serrano V S, Castellino F J
Abstract excerpt
In order to identify the regions of recombinant (r) tissue plasminogen activator (tPA) that mediate its kinetically relevant interaction with r-plasminogen activator inhibitor-1 (rPAI-1), we have determined the second-order association rate (k1) constants of domain-altered variants of tPA with rP...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cell Line
- Genetic Variation
- Humans
- Insecta
- Kinetics
- Macromolecular Substances
- Melanoma
- Molecular Sequence Data
- Oligonucleotide Probes
- Plasminogen Inactivators
- Recombinant Proteins
- Tissue Plasminogen Activator
- Tumor Cells, Cultured
- Urokinase-Type Plasminogen Activator