Article
Tissue-type plasminogen activator and its substrate Glu-plasminogen share common binding sites in limited plasmin-digested fibrin.
The Journal of biological chemistry - 15 Aug 1990
de Vries C, Veerman H, Koornneef E, Pannekoek H
Abstract excerpt
The enzyme tissue-type plasminogen activator (t-PA) and its substrate Glu-plasminogen can both bind to fibrin. The assembly of these three components results in about a 1000-fold acceleration of the conversion of Glu-plasminogen into plasmin. Fibrin binding of t-PA is mediated both by its finger...
Topics
- Binding Sites
- Binding, Competitive
- Chromosome Deletion
- Electrophoresis, Polyacrylamide Gel
- Fibrin
- Fibrinolysin
- Genetic Variation
- Humans
- Isoflurophate
- Kinetics
- Mutation
- Plasminogen
- Tissue Plasminogen Activator