Structural elements that govern the substrate specificity of the clot-dissolving enzyme plasmin.

Abstract excerpt

There is remarkable homology between the core structures of plasmin, a fibrin clot-degrading enzyme, and factor D, a complement-activating enzyme, despite markedly different biological functions. We postulated that sequence divergence in the loop structures between these two enzymes mediated the unique substrate and inhibitor interactions of plasmin. Recombinant microplasminogens chimerized with factor D...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Catalysis
• Share to Dose-Response Relationship, Drug
• Share to Fibrin