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Article

Tissue-type plasminogen activator mutants imitating urokinase in the peptide link between kringle and protease domains and at selected sites within the protease domain.

European journal of biochemistry - 1 Apr 1993

Hinzmann B, Wernicke D, Pfeifer M, Zacharias U, Fischer B, Eisenmenger F, Will H

Abstract excerpt

Tissue-type plasminogen activator (tPA) mutants which, at selected amino acid positions, mimic urokinase-type plasminogen activator (uPA) were expressed in Chinese hamster ovary cells and examined for their catalytic properties. In one series of mutants, the dipeptide Ser262 Thr263 between kringle 2 and the protease domain of tPA was (a) replaced by an Ala residue, (b) lengthened by additional Ser and Ala...

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Identifiers

PMID: 8386628
DOI: 10.1111/j.1432-1033.1993.tb17779.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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