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Article

Dynamic conformational changes in the rhesus TRIM5α dimer dictate the potency of HIV-1 restriction.

Virology - 1 Jan 2017

Lamichhane Rajan, Mukherjee Santanu, Smolin Nikolai, Pauszek Raymond F, Bradley Margret, Sastri Jaya, Robia Seth L, Millar David, Campbell Edward M

Abstract excerpt

The TRIM5α protein from rhesus macaques (rhTRIM5α) mediates a potent inhibition of HIV-1 infection via a mechanism that involves the abortive disassembly of the viral core. We have demonstrated that alpha-helical elements within the Linker 2 (L2) region, which lies between the SPRY domain and the Coiled-Coil domain, influence the potency of restriction. Here, we utilize single-molecule FRET analysis to reveal...

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Identifiers

PMID: 27821283
DOI: 10.1016/j.virol.2016.10.003
PMCID: PMC5327651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dynamic conformational changes in the rhesus TRIM5α dimer dictate the potency of HIV-1 restriction.PMID 27821283Read ↗

Restriction of HIV-1 by rhesus TRIM5α is governed by alpha helices in the Linker2 region.Semantic proximity Read ↗

Rhesus monkey TRIM5α SPRY domain recognizes multiple epitopes that span several capsid monomers on the surface of the HIV-1 mature viral core.Semantic proximity Read ↗

A B-box 2 surface patch important for TRIM5alpha self-association, capsid binding avidity, and retrovirus restriction.Semantic proximity Read ↗

Identification of residues within the L2 region of rhesus TRIM5alpha that are required for retroviral restriction and cytoplasmic body localization.Semantic proximity Read ↗

The Three-Fold Axis of the HIV-1 Capsid Lattice Is the Species-Specific Binding Interface for TRIM5α.Semantic proximity Read ↗

Binding of the rhesus TRIM5α PRYSPRY domain to capsid is necessary but not sufficient for HIV-1 restrictionSemantic proximity Read ↗

TRIM5α selectively binds a restriction-sensitive retroviral capsidSemantic proximity Read ↗

TRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus Monkeys.Semantic proximity Read ↗

Positive selection of primate <i>TRIM5</i> α identifies a critical species-specific retroviral restriction domainSemantic proximity Read ↗

Adaptation of HIV-1 to cells expressing rhesus monkey TRIM5α.Semantic proximity Read ↗

Determinants for the rhesus monkey TRIM5alpha-mediated block of the late phase of HIV-1 replication.Semantic proximity Read ↗

TRIM5 alpha drives SIVsmm evolution in rhesus macaques.Semantic proximity Read ↗

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