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Article

Structural basis of pre-mRNA recognition by the human cleavage factor Im complex.

Cell research - 1 Jul 2011

Li Heng, Tong Shuilong, Li Xu, Shi Hui, Ying Zheng, Gao Yongxiang, Ge Honghua, Niu Liwen, Teng Maikun

Abstract excerpt

The cleavage factor I(m) (CF I(m)), consists of a 25 kDa subunit (CF I(m)25) and one of three larger subunits (CF I(m)59, CF I(m)68, CF I(m)72), and is an essential protein complex for pre-mRNA 3'-end cleavage and polyadenylation. It recognizes the upstream sequence of the poly(A) site in a sequence-dependent manner. Here we report the crystal structure of human CF I(m), comprising CF I(m)25 and the RNA...

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Share to Crystallography, X-Ray
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21483454
DOI: 10.1038/cr.2011.67
PMCID: PMC3193493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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