Article
Association analysis of member RAS oncogene family gene polymorphisms with aspirin intolerance in asthmatic patients.
DNA and cell biology - 1 Mar 2014
Park Jong-Sook, Heo Jeong-Seok, Chang Hun Soo, Choi Inseon S, Kim Mi-Kyeong, Lee Jong-Uk, Park Byung Lae, Shin Hyoung Doo, Park Choon-Sik
Abstract excerpt
Member RAS oncogene family (RAB1A), a member of the RAS oncogene family, cycles between inactive GDP-bound and active GTP-bound forms regulating vesicle transport in exocytosis. Thus, functional alterations of the RAB1A gene may contribute to aspirin intolerance in asthmatic sufferers. To investigate the relationship between single-nucleotide polymorphisms (SNPs) in the RAB1A gene and aspirin-exacerbated...
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