Article
Association of four-locus gene interaction with aspirin-intolerant asthma in Korean asthmatics.
Journal of clinical immunology - 1 Jul 2008
Kim Seung-Hyun, Jeong Hyun-Hwan, Cho Bo-Young, Kim Myoungki, Lee Hyun-Young, Lee Jungseob, Wee Kyubum, Park Hae-Sim
Abstract excerpt
INTRODUCTION: Aspirin-intolerant asthma (AIA), a major clinical presentation of aspirin hypersensitivity, affects 10% of adult asthmatics. The genetic risk factors involved in the susceptibility to AIA have recently been investigated, but multilocus single-nucleotide polymorphisms (SNPs) associated with this susceptibility has not been evaluated. METHODS: We examined 246 asthmatic patients: 94 having aspirin...
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