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Article

Association analysis of thromboxane A synthase 1 gene polymorphisms with aspirin intolerance in asthmatic patients.

Pharmacogenomics - 1 Mar 2011

Oh Sun-Hee, Kim Yong-Hoon, Park Se-Min, Cho Sung-Hwan, Park Jong-Sook, Jang An-Soo, Park Sung-Woo, Uh Soo-Taek, Lee Youg-Mok, Kim Mi-Kyeong, Choi Inseon S, Cho Sang Heon, Hong Chein-Soo, Lee Yong Won, Lee Jae-Young, Choi Byoung Whui, Park Byung Lae, Shin Hyoung Doo, Park Choon-Sik

Abstract excerpt

AIM: Thromboxane A synthase (TBXAS1) converts prostaglandin H to thromboxane A, a potent constrictor of smooth respiratory muscle. Thus, functional alterations of the TBXAS1 gene may contribute to aspirin-intolerant asthma (AIA). MATERIALS & METHODS: We investigated the relationship between SNPs in the TBXAS1 gene and AIA. Asthmatics (n = 470) were categorized into AIA (20% or greater decreases in forced...

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Share to Adolescent
Share to Anti-Inflammatory Agents, Non-Steroidal
Share to Aspirin
Share to Forced Expiratory Volume
Share to Gene Frequency
Share to Genetic Diseases, Inborn
Share to Polymorphism, Genetic
Share to Young Adult

Source

Identifiers

PMID: 21449675
DOI: 10.2217/pgs.10.181

Genes

TBXAS1
FEV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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