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Article

Fetal and adult progenitors give rise to unique populations of CD8+ T cells.

Blood - 29 Dec 2016

Wang Jocelyn, Wissink Erin M, Watson Neva B, Smith Norah L, Grimson Andrew, Rudd Brian D

Abstract excerpt

During the ontogeny of the mammalian immune system, distinct lineages of cells arise from fetal and adult hematopoietic stem cells (HSCs) during specific stages of development. However, in some cases, the same immune cell type is produced by both HSC populations, resulting in the generation of phenotypically similar cells with distinct origins and divergent functional properties. In this report, we demonstrate...

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Identifiers

PMID: 28034872
DOI: 10.1182/blood-2016-06-725366
PMCID: PMC5201096

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