Article
PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer.
Scientific reports - 31 Aug 2017
Mjos Siv, Werner Henrica M J, Birkeland Even, Holst Frederik, Berg Anna, Halle Mari K, Tangen Ingvild L, Kusonmano Kanthida, Mauland Karen K, Oyan Anne M, Kalland Karl-Henning, Lewis Aurélia E, Mills Gordon B, Krakstad Camilla, Trovik Jone, Salvesen Helga B, Hoivik Erling A
Abstract excerpt
Mutations of the phosphoinositide-3-kinase (PI3K) catalytic subunit alpha gene (PIK3CA) are frequent in endometrial cancer. We sequenced exon9 and exon20 of PIK3CA in 280 primary endometrial cancers to assess the relationship with clinicopathologic variables, patient survival and associations with PIK3CA mRNA and phospho-AKT1 by gene expression and protein data, respectively. While PIK3CA mutations generally had...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.