Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Constrained RNA polymerase mutational pathways distinguish corallopyronin A resistance from rifampicin resistance in staphylococci.

Scientific reports - 30 Jul 2026

Karačić Jesenko, Karačić Sabina, Grosse Miriam, Schiefer Andrea, Pfarr Kenneth, Schneider Tanja, Hoerauf Achim, Bierbaum Gabriele

Abstract excerpt

Corallopyronin A (CorA) is a natural RNA polymerase (RNAP) inhibitor active against Gram-positive pathogens, including Staphylococcus aureus. Although spontaneous resistance to CorA occurs less frequently than to rifampicin, the genetic basis and evolutionary constraints of CorA resistance remain incompletely defined. Spontaneous mutation frequencies to CorA and rifampicin were determined by fluctuation analysis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diterpenes
Share to DNA-Directed RNA Polymerases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Lactones

Share to Rifampin

Share to Staphylococcus

Share to Staphylococcus aureus

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 42533047
DOI: 10.1038/s41598-026-64170-y
PMCID: PMC13424638

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constrained RNA polymerase mutational pathways distinguish corallopyronin A resistance from rifampicin resistance in staphylococci.PMID 42533047Read ↗

Activity of and development of resistance to corallopyronin A, an inhibitor of RNA polymerase.Semantic proximity Read ↗

Convergent Evolution Driven by Rifampin Exacerbates the Global Burden of Drug-Resistant Staphylococcus aureusSemantic proximity Read ↗

A laboratory-based predictive pathway for the development of Neisseria gonorrhoeae high-level resistance to corallopyronin A, an inhibitor of bacterial RNA polymerase.Semantic proximity Read ↗

The development of variation-based rifampicin resistance in Staphylococcus aureus deciphered through genomic and transcriptomic study.Semantic proximity Read ↗

The RpoB H₄₈₁Y rifampicin resistance mutation and an active stringent response reduce virulence and increase resistance to innate immune responses in Staphylococcus aureus.Semantic proximity Read ↗

Evolution of resistance mechanisms and biological characteristics of rifampicin-resistant Staphylococcus aureus strains selected in vitroSemantic proximity Read ↗

Characterization of mutations in the rpoB gene that confer rifampin resistance in Staphylococcus aureus.Semantic proximity Read ↗

Evaluating the activity of the RNA polymerase inhibitor myxopyronin B against Staphylococcus aureus.Semantic proximity Read ↗

Efflux pump activation confers mupirocin resistance and enhances rhizosphere fitness in Pseudomonas.Semantic proximity Read ↗

Staphylococcus aureus COL : An Atypical Model Strain of MRSA That Exhibits Slow Growth and Antibiotic Tolerance due to a Mutation in PRPP SynthetaseSemantic proximity Read ↗

In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: microbiology profiling studies with staphylococci and streptococci.Semantic proximity Read ↗

Analysing the fitness cost of antibiotic resistance to identify targets for combination antimicrobials.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.