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Article

Activity of and development of resistance to corallopyronin A, an inhibitor of RNA polymerase.

Antimicrobial agents and chemotherapy - 1 May 2011

Mariner Katherine, McPhillie Martin, Trowbridge Rachel, Smith Catriona, O'Neill Alex J, Fishwick Colin W G, Chopra Ian

Abstract excerpt

We explored the properties of corallopyronin A (CorA), a poorly characterized inhibitor of bacterial RNA polymerase (RNAP). It displayed a 50% inhibitory concentration of 0.73 μM against RNAP, compared with 11.5 nM for rifampin. The antibacterial activity of CorA was also inferior to rifampin, and resistant mutants of Staphylococcus aureus were easily selected. The mutations conferring resistance resided in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21321139
DOI: 10.1128/AAC.01742-10
PMCID: PMC3088244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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