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Antibiotics GE23077, Novel Inhibitors of Bacterial RNA Polymerase I. Taxonomy, Isolation and Characterization

1 Jan 2004

Abstract excerpt

GE 23077 factors A1, A2, B1 and B2 are novel antibiotics isolated from fermentation broths of an Actinomadura sp. strain. GE23077 antibiotics are cyclic peptides, which inhibit Escherichia coli RNA polymerase at nM concentrations. Both rifampicin-sensitive and rifampicin-resistant polymerases are inhibited, whereas E. coli DNA polymerase and wheat germ RNA polymerase are substantially not affected. In spite of...

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PMID: 15152807
DOI: 10.7164/antibiotics.57.210

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