Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequency, spectrum, and nonzero fitness costs of resistance to myxopyronin in Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Dec 2012

Srivastava Aashish, Degen David, Ebright Yon W, Ebright Richard H

Abstract excerpt

The antibiotic myxopyronin (Myx) functions by inhibiting bacterial RNA polymerase (RNAP). The binding site on RNAP for Myx-the RNAP "switch region SW1/SW2 subregion"-is different from the binding site on RNAP for the RNAP inhibitor currently used in broad-spectrum antibacterial therapy, rifampin (Rif). Here, we report the frequency, spectrum, and fitness costs of Myx resistance in Staphylococcus aureus. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Colony Count, Microbial
Share to DNA-Directed RNA Polymerases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Lactones

Share to Methicillin-Resistant Staphylococcus aureus

Share to Rifampin

Share to Staphylococcus aureus

Source

Open in PubMed Open full text

Identifiers

PMID: 23006749
DOI: 10.1128/AAC.01060-12
PMCID: PMC3497154

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequency, spectrum, and nonzero fitness costs of resistance to myxopyronin in Staphylococcus aureus.PMID 23006749Read ↗

Evaluating the activity of the RNA polymerase inhibitor myxopyronin B against Staphylococcus aureus.Semantic proximity Read ↗

Hidden antibiotic resistance fitness costs revealed by GWAS-based epistasis analysisSemantic proximity Read ↗

Constrained RNA polymerase mutational pathways distinguish corallopyronin A resistance from rifampicin resistance in staphylococci.Semantic proximity Read ↗

Analysing the fitness cost of antibiotic resistance to identify targets for combination antimicrobials.Semantic proximity Read ↗

Molecular genetic and structural modeling studies of Staphylococcus aureus RNA polymerase and the fitness of rifampin resistance genotypes in relation to clinical prevalence.Semantic proximity Read ↗

Rifampin Resistance rpoB Alleles or Multicopy Thioredoxin/Thioredoxin Reductase Suppresses the Lethality of Disruption of the Global Stress Regulator spx in Staphylococcus aureus.Semantic proximity Read ↗

Rifampicin resistance in Staphylococcus epidermidis: molecular characterisation and fitness cost of rpoB mutations.Semantic proximity Read ↗

Biological cost of rifampin resistance from the perspective of Staphylococcus aureus.Semantic proximity Read ↗

Linking system-wide impacts of RNA polymerase mutations to the fitness cost of rifampin resistance in Pseudomonas aeruginosa.Semantic proximity Read ↗

Analysis of mupirocin resistance and fitness in Staphylococcus aureus by molecular genetic and structural modeling techniques.Semantic proximity Read ↗

Physiological cost of rifampin resistance induced in vitro in Mycobacterium tuberculosis.Semantic proximity Read ↗

Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.