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Article

In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Jul 2008

Robertson Gregory T, Bonventre Eric J, Doyle Timothy B, Du Qun, Duncan Leonard, Morris Timothy W, Roche Eric D, Yan Dalai, Lynch A Simon

Abstract excerpt

Rifamycins have proven efficacy in the treatment of persistent bacterial infections. However, the frequency with which bacteria develop resistance to rifamycin agents restricts their clinical use to antibiotic combination regimens. In a program directed toward the synthesis of rifamycins with a lower propensity to elicit resistance development, a series of compounds were prepared that covalently combine rifamycin...

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Identifiers

PMID: 18443108
DOI: 10.1128/AAC.01649-07
PMCID: PMC2443886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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