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MADDD-seq, a novel massively parallel sequencing tool for simultaneous detection of DNA damage and mutations.

Nucleic acids research - 9 Sept 2024

Vermulst Marc, Paskvan Samantha L, Chung Claire S, Franke Kathryn, Clegg Nigel, Minot Sam, Madeoy Jennifer, Long Annalyssa S, Gout Jean-Francois, Bielas Jason H

Abstract excerpt

Our genome is exposed to a wide variety of DNA-damaging agents. If left unrepaired, this damage can be converted into mutations that promote carcinogenesis or the development of genetically inherited diseases. As a result, researchers and clinicians require tools that can detect DNA damage and mutations with exceptional sensitivity. In this study, we describe a massively parallel sequencing tool termed Mutation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39149908
DOI: 10.1093/nar/gkae632
PMCID: PMC11381349

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