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Article

Novel evidence suggests Hepatitis B virus surface proteins participate in regulation of HBV genome replication.

Virologica Sinica - 1 Apr 2011

Qiu Jian, Qin Bo, Rayner Simon, Wu Chun-chen, Pei Rong-juan, Xu Song, Wang Yun, Chen Xin-wen

Abstract excerpt

Naturally occurring mutations in surface proteins of Hepatitis B virus (HBV) usually result in altered hepatitis B surface antigen (HBsAg) secretion efficiency. In the present study, we reported two conserved residues, M75 and M103 with respect to HBsAg, mutations of which not only attenuated HBsAg secretion (M75 only), but also suppressed HBV genome replication without compromising the overlapping p-gene...

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Identifiers

PMID: 21468936
DOI: 10.1007/s12250-011-3190-0
PMCID: PMC8222424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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