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Article

Increasing power of genome-wide association studies by collecting additional single-nucleotide polymorphisms.

Genetics - 1 Jun 2011

Kostem Emrah, Lozano Jose A, Eskin Eleazar

Abstract excerpt

Genome-wide association studies (GWASs) have been effectively identifying the genomic regions associated with a disease trait. In a typical GWAS, an informative subset of the single-nucleotide polymorphisms (SNPs), called tag SNPs, is genotyped in case/control individuals. Once the tag SNP statistics are computed, the genomic regions that are in linkage disequilibrium (LD) with the most significantly associated...

Topics

Algorithms
Arthritis, Rheumatoid
Coronary Artery Disease
Crohn Disease
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Genetic Predisposition to Disease
Genome, Human
Genome-Wide Association Study
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Linkage Disequilibrium

Models, Genetic

Polymorphism, Single Nucleotide

Reproducibility of Results

Source

Open in PubMed Open full text

Identifiers

PMID: 21467568
DOI: 10.1534/genetics.111.128595
PMCID: PMC3122306

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21467568-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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