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Article

On the follow-up of genome-wide association studies: an overall test for the most promising SNPs.

Genetic epidemiology - 1 Jul 2011

Lipman Peter J, Cho Michael H, Bakke Per, Gulsvik Amund, Kong Xiangyang, Lomas David A, Anderson Wayne, Silverman Edwin K, Lange Christoph

Abstract excerpt

Even in large-scale genome-wide association studies (GWASs), only a fraction of the true associations are detected at the genome-wide significance level. When few or no associations reach the significance threshold, one strategy is to follow up on the most promising candidates, i.e. the single nucleotide polymorphisms (SNPs) with the smallest association-test P-values, by genotyping them in additional studies. In...

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PMID: 21374717
DOI: 10.1002/gepi.20578
PMCID: PMC4096304

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