Article
Evaluating the power to discriminate between highly correlated SNPs in genetic association studies.
Genetic epidemiology - 1 Jul 2010
Udler Miriam S, Tyrer Jonathan, Easton Douglas F
Abstract excerpt
Neighboring common polymorphisms are often correlated (in linkage disequilibrium (LD)) as a result of shared ancestry. An association between a polymorphism and a disease trait may therefore be the indirect result of a correlated functional variant, and identifying the true causal variant(s) from an initial disease association is a major challenge in genetic association studies. Here, we present a method to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.