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Article

High CD133 expression levels in gastrointestinal stromal tumors.

Cytometry. Part B, Clinical cytometry - 1 Jan 2000

Bozzi Fabio, Conca Elena, Manenti Giacomo, Negri Tiziana, Brich Silvia, Gronchi Alessandro, Pierotti Marco A, Tamborini Elena, Pilotti Silvana

Abstract excerpt

BACKGROUND: Gastrointestinal stromal tumours (GISTs) have activating KIT or PDGFRA gene mutations. Imatinib mesylate, which targets KIT and PDGFRA, is effective in treating GISTs, but 90% of GIST patients become imatinib-resistant as a result of acquiring secondary KIT mutations. Recent findings suggest that tumour growth can be driven by mutated self-renewing progenitors known as cancer stem cells (CSCs), which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21462307
DOI: 10.1002/cyto.b.20589

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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