Article
Evolution from heterozygous to homozygous KIT mutation in gastrointestinal stromal tumor correlates with the mechanism of mitotic nondisjunction and significant tumor progression.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2008
Chen Lei L, Holden Joseph A, Choi Haesun, Zhu Jing, Wu Elsie F, Jones Kimberly A, Ward John H, Andtbacka Robert H, Randall R Lor, Scaife Courtney L, Hunt Kelly K, Prieto Victor G, Raymond Austin K, Zhang Wei, Trent Jonathan C, Benjamin Robert S, Frazier Marsha L
Abstract excerpt
Activating mutation in KIT or platelet-derived growth factor-alpha can lead to gastrointestinal stromal tumors (GISTs). Eighty-four cases from two institutes were analyzed. Of them, 62 (74%) harbored KIT mutations, 7 of which are previously unreported. One exhibited duplication from both intron 1...
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