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Article

Embryonic stem cell factor FOXD3 (Genesis) defects in gastrointestinal stromal tumors.

Endocrine-related cancer - 1 Oct 2023

Faucz Fabio R, Horvath Anelia D, Assié Guillaume, Almeida Madson Q, Szarek Eva, Boikos Sosipatros, Angelousi Anna, Levy Isaac, Maria Andrea G, Chitnis Ajay, Antonescu Cristina R, Claus Rainer, Bertherat Jérôme, Plass Christoph, Eng Charis, Stratakis Constantine A

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms, believed to originate from the interstitial cells of Cajal (ICC), often caused by overexpression of tyrosine kinase receptors (TKR) KIT or PDGFRA. Here, we present evidence that the embryonic stem cell factor FOXD3, first identified as 'Genesis' and involved in both gastrointestinal and neural crest cell development, is implicated in GIST...

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Comparative Genomic Hybridization
Embryonic Stem Cells
Forkhead Transcription Factors
Gastrointestinal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gastrointestinal Stromal Tumors

Proto-Oncogene Proteins c-kit

Receptor, Platelet-Derived Growth Factor alpha

Stem Cell Factor

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Identifiers

PMID: 37578265
DOI: 10.1530/ERC-23-0067
PMCID: PMC10564589

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