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Article

Mutations in the Ras-Raf Axis underlie the prognostic value of CD133 in colorectal cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2012

Kemper Kristel, Versloot Miranda, Cameron Katherine, Colak Selçuk, de Sousa e Melo Felipe, de Jong Joan H, Bleackley Joanne, Vermeulen Louis, Versteeg Rogier, Koster Jan, Medema Jan Paul

Abstract excerpt

PURPOSE: High expression of cancer stem cell (CSC) marker CD133 has been used as a predictor for prognosis in colorectal cancer (CRC), suggesting that enumeration of CSCs, using CD133, is predictive for disease progression. However, we showed recently that both CD133 mRNA and protein are not downregulated during differentiation of colon CSCs, pointing to an alternative reason for the prognostic value of CD133. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22496204
DOI: 10.1158/1078-0432.CCR-11-3066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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