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Article

Kitlow stem cells cause resistance to Kit/platelet-derived growth factor alpha inhibitors in murine gastrointestinal stromal tumors.

Gastroenterology - 1 Sept 2010

Bardsley Michael R, Horváth Viktor J, Asuzu David T, Lorincz Andrea, Redelman Doug, Hayashi Yujiro, Popko Laura N, Young David L, Lomberk Gwen A, Urrutia Raul A, Farrugia Gianrico, Rubin Brian P, Ordog Tamas

Abstract excerpt

BACKGROUND & AIMS: Gastrointestinal stromal tumors (GIST) are related to interstitial cells of Cajal (ICC) and often contain activating stem cell factor receptor (Kit) or platelet-derived growth factor receptor alpha (Pdgfra) mutations. Kit/Pdgfra inhibitors such as imatinib mesylate have increased progression-free survival in metastatic GIST but are not curative. In mouse models we investigated whether Kit(low)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20621681
DOI: 10.1053/j.gastro.2010.05.083
PMCID: PMC2933938

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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