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Article

Etodolac preserves cartilage-specific phenotype in human chondrocytes: effects on type II collagen synthesis and associated mRNA levels.

European journal of rheumatology and inflammation - 1 Jan 1990

Goldring M B, Sohbat E, Elwell J M, Chang J Y

Abstract excerpt

We have shown that interleukin-1 (IL-1) suppresses expression of cartilage-specific types II and IX collagens by cultured human chondrocytes. This inhibition is potentiated by agents which block IL-1-stimulated PGE2 production (J. Clin. Invest. 82:2026, 1988). In contrast, expression of types I a...

Topics

Anti-Inflammatory Agents, Non-Steroidal
Cartilage
Cells, Cultured
Collagen
Dinoprostone
Etodolac
Fibronectins
Humans
Indoleacetic Acids
Indomethacin
Ketoprofen
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Procollagen

RNA, Messenger

Time Factors

Source

Identifiers

PMID: 2146129

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2146129-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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