Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of lysyl oxidase activity can delay phenotypic modulation of chondrocytes in two-dimensional culture.

Osteoarthritis and cartilage - 1 Feb 2005

Farjanel J, Sève S, Borel A, Sommer P, Hulmes D J S

Abstract excerpt

OBJECTIVE: Chondrocytes frequently de-differentiate in two-dimensional (2D) culture, especially in the presence of serum. To examine the role of lysyl oxidase (LOX) induced cross-linking in this phenomenon, the effect of the specific LOX inhibitor beta-aminopropionitrile (BAPN) was studied in 2D chondrocyte culture. DESIGN: Chick embryo sternal chondrocytes (both proliferative and hypertrophic, from caudal and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Western
Share to Chick Embryo
Share to Chondrocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Culture Media, Conditioned

Share to Culture Media, Serum-Free

Share to Enzyme Inhibitors

Share to Fluorescent Antibody Technique

Share to Protein-Lysine 6-Oxidase

Source

Identifiers

PMID: 15694573
DOI: 10.1016/j.joca.2004.06.015

Genes

LOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of lysyl oxidase activity can delay phenotypic modulation of chondrocytes in two-dimensional culture.PMID 15694573Read ↗

Recombinant lysyl oxidase effects on embryonic tendon cell phenotype and behavior.Semantic proximity Read ↗

Immortalized cell lines from mouse xiphisternum preserve chondrocyte phenotype.Semantic proximity Read ↗

Contacts with fibrils containing collagen I, but not collagens II, IX, and XI, can destabilize the cartilage phenotype of chondrocytes.Semantic proximity Read ↗

Cartilage oligomeric matrix protein (COMP) and collagen IX are sensitive markers for the differentiation state of articular primary chondrocytes.Semantic proximity Read ↗

Induction of hypertrophic chondrocyte-like phenotypes by oxidized LDL in cultured bovine articular chondrocytes through increase in oxidative stress.Semantic proximity Read ↗

Two-dimensional electrophoresis of intracellular and secreted protein synthesized by fetal bovine chondrocytes in high-density culture.Semantic proximity Read ↗

Expression of Lysyl Oxidase Family Enzymes During Human Endometrial DecidualizationSemantic proximity Read ↗

Lysyl Oxidase Activity Is Required for Ordered Collagen Fibrillogenesis by Tendon CellsSemantic proximity Read ↗

Lysyl Oxidase Activity Is Dysregulated during Impaired Alveolarization of Mouse and Human LungsSemantic proximity Read ↗

Control of human articular chondrocyte differentiation by reduced oxygen tension.Semantic proximity Read ↗

Lysyl oxidase is required for vascular and diaphragmatic development in mice.Semantic proximity Read ↗

Expression of collagen and fiber-associated proteins in human septal cartilage during in vitro dedifferentiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.