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Article

Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis.

Arthritis research & therapy - 1 Jan 2010

El-Bikai Rana, Welman Mélanie, Margaron Yoran, Côté Jean-François, Macqueen Luke, Buschmann Michael D, Fahmi Hassan, Shi Qin, Maghni Karim, Fernandes Julio C, Benderdour Mohamed

Abstract excerpt

INTRODUCTION: Objectives were to investigate whether interactions between human osteoarthritic chondrocytes and 4-hydroxynonenal (HNE)-modified type II collagen (Col II) affect cell phenotype and functions and to determine the protective role of carnosine (CAR) treatment in preventing these effects. METHODS: Human Col II was treated with HNE at different molar ratios (MR) (1:20 to 1:200; Col II:HNE). Articular...

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Identifiers

PMID: 20977750
DOI: 10.1186/ar3173
PMCID: PMC2991038

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Source receipt: pubmed, retrieved 7 Sept 2026.

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