Article
Effects of tumor necrosis factor alpha on proliferation and expression of differentiated phenotypes in rabbit costal chondrocytes in culture.
Calcified tissue international - 1 Sept 1990
Enomoto M, Pan H O, Kinoshita A, Yutani Y, Suzuki F, Takigawa M
Abstract excerpt
Tumor necrosis factor alpha (TNF alpha) decreased the synthesis of glycosaminoglycan (GAG) in rabbit costal chondrocytes in culture, but did not stimulate the release of GAG from cell layers. Like chondrocytes cultured in control medium, chondrocytes cultured in the presence of TNF alpha produced putative "cartilage-specific" proteoglycans identified by density gradient centrifugation under dissociative...
Topics
- Alkaline Phosphatase
- Animals
- Cartilage
- Cell Differentiation
- Cell Division
- Cells, Cultured
- DNA
- Epidermal Growth Factor
- Fibroblast Growth Factors
- Glycosaminoglycans
- Growth Plate