Article
Quantification of expression levels of cellular differentiation markers does not support a general shift in the cellular phenotype of osteoarthritic chondrocytes.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Jan 2003
Gebhard Pia Margarethe, Gehrsitz Angelika, Bau Brigitte, Söder Stephan, Eger Wolfgang, Aigner Thomas
Abstract excerpt
Many studies have shown increased anabolic activity in osteoarthritic cartilage and have suggested changes in the cellular phenotypes of articular chondrocytes. Most of these studies relied on non-quantitative technologies, which did not allow the estimation of the relative importance of the different differentiation phenomena. In the present study, we developed and used quantitative PCR assays for collagen types...
Topics
- Adult
- Aged
- Biomarkers
- Cartilage, Articular
- Cell Differentiation
- Chondrocytes
- Collagen Type I
- Collagen Type II
- Collagen Type III
- Collagen Type X
- Gene Expression
- Humans
- Middle Aged