Article
Differential expression of mRNAs for endopeptidases in phenotypically modulated ('dedifferentiated') human articular chondrocytes.
FEBS letters - 4 Aug 1997
Kostoulas G, Lang A, Trueb B, Baici A
Abstract excerpt
Human articular chondrocytes modulated away from their original phenotype by serial subcultures in monolayer differentially express mRNAs for endopeptidases. The mRNAs for the cathepsins B and L are extremely low in differentiated cells, but are soon expressed in parallel with the loss of the dif...
Topics
- Adult
- Cartilage, Articular
- Cathepsin B
- Cathepsin L
- Cathepsins
- Cell Differentiation
- Cells, Cultured
- Collagenases
- Cysteine Endopeptidases
- Endopeptidases
- Humans
- Male
- Matrix Metalloproteinase 3
- Phenotype
- Proteins
- RNA, Messenger
- Tissue Inhibitor of Metalloproteinase-2