Article
Rationale for an international consortium to study inherited genetic susceptibility to childhood acute lymphoblastic leukemia.
Haematologica - 1 Jul 2011
Sherborne Amy L, Hemminki Kari, Kumar Rajiv, Bartram Claus R, Stanulla Martin, Schrappe Martin, Petridou Eleni, Semsei Agnes F, Szalai Csaba, Sinnett Daniel, Krajinovic Maja, Healy Jasmine, Lanciotti Marina, Dufour Carlo, Indaco Stefania, El-Ghouroury Eman A, Sawangpanich Ruchchadol, Hongeng Suradej, Pakakasama Samart, Gonzalez-Neira Anna, Ugarte Evelia L, Leal Valeria P, Espinoza Juan P M, Kamel Azza M, Ebid Gamal T A, Radwan Eman R, Yalin Serap, Yalin Erdinc, Berkoz Mehmet, Simpson Jill, Roman Eve, Lightfoot Tracy, Hosking Fay J, Vijayakrishnan Jayaram, Greaves Mel, Houlston Richard S
Abstract excerpt
Acute lymphoblastic leukemia is the major pediatric cancer in developed countries. To date most association studies of acute lymphoblastic leukemia have been based on the candidate gene approach and have evaluated a restricted number of polymorphisms. Such studies have served to highlight difficulties in conducting statistically and methodologically rigorous investigations into acute lymphoblastic leukemia risk....
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