Article
Monitoring endosomal trafficking of the g protein-coupled receptor somatostatin receptor 3.
Methods in enzymology - 1 Jan 2014
Tower-Gilchrist Cristy, Styers Melanie L, Yoder Bradley K, Berbari Nicolas F, Sztul Elizabeth
Abstract excerpt
Endocytic trafficking of G protein-coupled receptors (GPCRs) regulates the number of cell surface receptors available for activation by agonists and serves as one mechanism that controls the intensity and duration of signaling. Deregulation of GPCR-mediated signaling pathways results in a multitude of diseases, and thus extensive efforts have been directed toward understanding the pathways and molecular events...
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