Article
Ubiquitylation of leptin receptor OB-Ra regulates its clathrin-mediated endocytosis.
The EMBO journal - 8 Mar 2006
Belouzard Sandrine, Rouillé Yves
Abstract excerpt
Leptin receptors are constitutively endocytosed in a ligand-independent manner. To study their endocytosis, leptin receptors OB-Ra and OB-Rb were expressed in HeLa cells. Both receptor isoforms were ubiquitylated, internalized by clathrin-mediated endocytosis and transported to Hrs-positive endosomes after their internalization. Proteasome inhibitors inhibited OB-Ra but not OB-Rb internalization from the cell...
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