Article
Rab14 regulates apical targeting in polarized epithelial cells.
Traffic (Copenhagen, Denmark) - 1 Jul 2008
Kitt Khameeka N, Hernández-Deviez Delia, Ballantyne Sarah D, Spiliotis Elias T, Casanova James E, Wilson Jean M
Abstract excerpt
Epithelial cells display distinct apical and basolateral membrane domains, and maintenance of this asymmetry is essential to the function of epithelial tissues. Polarized delivery of apical and basolateral membrane proteins from the trans Golgi network (TGN) and/or endosomes to the correct domain requires specific cytoplasmic machinery to control the sorting, budding and fission of vesicles. However, the...
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