Article
DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β-γ Bridging Group of the Incoming dNTP.
Biochemistry - 10 Oct 2017
Alnajjar Khadijeh S, Negahbani Amirsoheil, Nakhjiri Maryam, Krylov Ivan S, Kashemirov Boris A, McKenna Charles E, Goodman Myron F, Sweasy Joann B
Abstract excerpt
The hydrophobic hinge region of DNA polymerase β (pol β) is located between the fingers and palm subdomains. The hydrophobicity of the hinge region is important for maintaining the geometry of the binding pocket and for the selectivity of the enzyme. Various cancer-associated pol β variants in the hinge region have reduced fidelity resulting from a decreased discrimination at the level of dNTP binding....
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