Article
BRCT domain of DNA polymerase μ has DNA-binding activity and promotes the DNA polymerization activity.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Sept 2012
Matsumoto Takuro, Go Kaori, Hyodo Mariko, Koiwai Kotaro, Maezawa So, Hayano Takahide, Suzuki Masahiro, Koiwai Osamu
Abstract excerpt
DNA polymerase μ (pol μ) catalyzes nonhomologous end-joining in DNA double-stranded break repair. Pol μ consists of an amino-terminal BRCA1 carboxyl-terminal homology (BRCT) domain and a pol β-like region, which contains the catalytic site. By DNA cellulose column chromatography, using full-length pol μ and five different deletion mutants, we found that the amino-terminal region has double-stranded DNA...
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